My response to a Sanford apollogist in a forum:
John Sanford, like the great Young Earth Creationist scientist? You rely on the scientific authority of a deluted man that think that the earth is 6000 years old…
This is getting better and better…
That statement of poor Dr Sanford was based on the work of Crow and Kondrashov, which does not correpond to reality! Empirically we see that species are not extinguished after a few generations. He also made a computer program that proves the quick doom of species… In no way poor Dr. Sanford was arbitrary! But let me give you an example:
In my personal experience, I work with a bacteria that was isolated in the 50′s from the genus Streptomyces. Given that the cultures are renewed on a weekly basis in many different labs around the globe, I think we must be working with virtual bacteria. Believe me they do not present signs of early senescence. Remember, bacteria do not possess a separation of somatic/ germ cell line, it’s all directly inherited. Antibiotic overproducing strains (quite a nice trait to have in the environment! Yep that’s right adaptive advantage) often arise from random mutation screenings with UV light! In fact, pharmaceutical companies use this method to obtain optimized strains. So you see, those mean bacteria that resist genetic entropy empirically refutes poor Dr. Sanford…
If you really want to validate something, you cannot purely rely on mathematical models, bench work is the way! And for what is worth, bacteria would be a tremendous model to test the genetic entropy hypothesis.
Other verified examples:
What is deleterious or positive is not up to you to decide or poor Dr. Sanford! The final judge will be natural selection or genetic drift phenomena. A mutation that is deleterious in one sense may be highly beneficial in other: the example of sikle cell anemia/ malaria illustrates that! Even a putative neutral mutation can be positive in some scenarios: the example of people who are naturally resistant to HIV illustrates that! Environment is an ever-changing madaf****, so adapt or perish!
Therefore, genetic entropy is bogus and the book of poor Dr. Sanford should be renamed from “Genetic Entropy & The Mystery of the Genome” into “On the doom of species – How do I mistify the Genome”.
I’ll grant you this, I’ve made one assumption during this debate. I’ve assumed that you were an idiot! But even that has been validated empirically.
I rest my case.
John Sanford… Seriously?! Hilarious!